Brain Circuit Shows How Dopamine Controls Animal Behavior

Brain Circuit Shows How Dopamine Controls Animal Behavior

Sreekanth: Imagine a dice game. In option
one, you would either get $100 or you could get $0. If you roll number 6, you get that
$100. For any other number that you got, you would get $0. In the second scenario, you
roll the dice once again and get a constant $5. Which one would you choose? Most people would choose the second scenario
because you’re guaranteed that $5. So animals, just like us, also tend to do the same thing.
In the case of the animal, the reward is measured by food, so animals prefer an environment
where you get more constant food as opposed to environments where food is more available. Tatyana: One of the challenges in neuroscience
is to understand and predict animals’ and human behavior. So, in an effort to obtain
a tractable model, we turn to a little worm, C. elegans, because they have a simple nervous
system and they use these very similar decision-making principles compared to us. Sreekanth: We discovered how the nervous system
evaluates the availability in the environment and uses that information to modify the animal’s
behavior. Now, it uses that availability to talk to a cell that produces dopamine and
increases dopamine in the condition where you have high availability. This dopamine
then modifies that animal’s behavioral strategy so that it can seek more constant environments. Tatyana: There is an assumption in the field
that behavior of animals is really variable, and the way I would react to a situation would
be very different from someone else. And what we discovered, that to a large extent, the
animal’s behavior is actually predictable given their past set of experiences. Sreekanth: We have identified the signaling
pathway that dopamine is using to modify animals’ behavioral strategy, so we hope that this
work is going to lead to a greater understanding and eventual therapies for a large number
of neurodegenerative diseases like Parkinson’s. And part of the reason for assuming that is
because changes in dopamine signaling pathway underlie these different diseases like Parkinson’s,
and so, if you understood how dopamine signaling worked in the brain, you could potentially
help patients whose dopamine signaling was disrupted.

5 thoughts on “Brain Circuit Shows How Dopamine Controls Animal Behavior

  1. WATCH: Newly Discovered Brain Circuit Shows How Dopamine Controls Animal Behavior: via @YouTube #neuroscience

  2. Dopamine helps with math rules as well as mood.

  3. Well I must be ahead of these guys because I know how to make my brain produce dopamine by thinking about it. Which helps me with my ADHD and dyslexia. I can read more sufficiently I'm more calm more introverted more relaxed I feel a ride array of different benefits from unlocking this ability.

  4. Increased Oxidative stress from chronic insulin resistance due to high dietary carb intake is major contributor to Parkinsons Disease.

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